Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study
Identifieur interne : 000407 ( France/Analysis ); précédent : 000406; suivant : 000408Effect of levodopa on pain threshold in Parkinson's disease: A clinical and positron emission tomography study
Auteurs : Christine Brefel-Courbon [France] ; Pierre Payoux [France] ; Claire Thalamas [France] ; Fabienne Ory [France] ; Isabelle Quelven [France] ; François Chollet [France] ; Jean Louis Montastruc [France] ; Olivier Rascol [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-12.
English descriptors
- KwdEn :
- Aged, Antiparkinson Agents (therapeutic use), Brain Mapping, Case-Control Studies, Cerebral Cortex (blood supply), Cerebrovascular Circulation (drug effects), H215O positron emission tomography, Humans, Levodopa (therapeutic use), Middle Aged, Pain (drug therapy), Pain (etiology), Pain Clinics, Pain Measurement (methods), Pain Threshold (drug effects), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson's disease, Positron-Emission Tomography, levodopa, pain threshold.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- blood supply : Cerebral Cortex.
- drug effects : Cerebrovascular Circulation, Pain Threshold.
- drug therapy : Pain, Parkinson Disease.
- etiology : Pain.
- methods : Pain Measurement.
- physiopathology : Parkinson Disease.
- Aged, Brain Mapping, Case-Control Studies, Humans, Middle Aged, Pain Clinics, Positron-Emission Tomography.
Abstract
Patients suffering from Parkinson's disease (PD) frequently experienced painful sensations that could be in part due to central modification of nociception. We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H215O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20629
Affiliations:
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We compared pain threshold before and after administration of levodopa in PD patients and in controls, and investigated cerebral activity with positron emission tomography (PET) during experimental nociceptive stimulation. Pain threshold was determined using thermal stimulation during two randomized conditions: off and on. We performed H215O PET analysis of regional cerebral blood flow on subjects while they received alternate randomized noxious and innocuous stimuli during off and on conditions. In off condition, pain threshold in nine PD patients was significantly lower than in nine controls. Administration of levodopa significantly raised pain threshold in PD patients but not in controls. During off condition, there was a significant increase in pain‐induced activation in right insula and prefrontal and left anterior cingulate cortices in PD compared to control group. Levodopa significantly reduced pain‐induced activation in these areas in PD. This study shows that pain threshold is lower in PD patients but returns to normal ranges after levodopa administration. Moreover, PD patients have higher pain‐induced activation in nociceptive pathways, which can be reduced by levodopa. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Midi-Pyrénées</li></region><settlement><li>Toulouse</li></settlement><orgName><li>Université Toulouse III - Paul Sabatier</li><li>Université de Toulouse</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name></noRegion><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name><name sortKey="Brefel Ourbon, Christine" sort="Brefel Ourbon, Christine" uniqKey="Brefel Ourbon C" first="Christine" last="Brefel-Courbon">Christine Brefel-Courbon</name><name sortKey="Chollet, Francois" sort="Chollet, Francois" uniqKey="Chollet F" first="François" last="Chollet">François Chollet</name><name sortKey="Chollet, Francois" sort="Chollet, Francois" uniqKey="Chollet F" first="François" last="Chollet">François Chollet</name><name sortKey="Montastruc, Jean Louis" sort="Montastruc, Jean Louis" uniqKey="Montastruc J" first="Jean Louis" last="Montastruc">Jean Louis Montastruc</name><name sortKey="Ory, Fabienne" sort="Ory, Fabienne" uniqKey="Ory F" first="Fabienne" last="Ory">Fabienne Ory</name><name sortKey="Payoux, Pierre" sort="Payoux, Pierre" uniqKey="Payoux P" first="Pierre" last="Payoux">Pierre Payoux</name><name sortKey="Quelven, Isabelle" sort="Quelven, Isabelle" uniqKey="Quelven I" first="Isabelle" last="Quelven">Isabelle Quelven</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Rascol, Olivier" sort="Rascol, Olivier" uniqKey="Rascol O" first="Olivier" last="Rascol">Olivier Rascol</name><name sortKey="Thalamas, Claire" sort="Thalamas, Claire" uniqKey="Thalamas C" first="Claire" last="Thalamas">Claire Thalamas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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